Postdoc : Fluid flow simulations in bone

The Biomechanics Section (BMe) is a multi-disciplinary institute situated in the Department of Mechanical Engineering. We aim to generate new knowledge of the mechanical behaviour, function and organization of cells and tissues and develop innovative solutions to prevent, diagnose, monitor, treat and cure diseases and health problems that have a mechanical origin or component at the cell or tissue level. Our division is having a strong expertise in both experimental and numerical analyses of human structure and function. Research topics cover the broad spectrum of length scales present in the human body : from cells to tissues and from organs to the entire body and its interaction with the environment. Research is clustered around four main topics : tissue and implant mechanics, mechanobiology and tissue engineering, surgical systems technology, and rehabilitation and prevention biomechanics. Many projects run in collaboration with clinical partners. The research activities are reflected in the teaching activities of the division, ranging from basic engineering mechanics to dedicated courses in the field of biomedical engineering.

Responsibilities

In the knee, as in all joints, cartilage covers the bone. How does nature solve the challenging problem of connecting two tissues as diverse as cartilage and bone? What are the structural and mechanical characteristics of this interface and how does it change in osteoarthritis (OA)? Does it play a role in the onset and development of OA? In a large collaborative project between KU Leuven, U.Liege, U.Sheffield, and U.Melbourne we are addressing these issues. We investigate fundamental biomechanical and mechanobiological aspects of subchondral bone, mineralized cartilage and hyaline cartilage, with a particular emphasis on the bone-cartilage interface. We aim to quantify material characteristics and mechanical properties of the interface region, and clarify load-induced modifications in this region, which is one of the least understood and least investigated locations in the musculoskeletal system and yet fundamental to joint health. We are seeking to expand the team at KU Leuven with one postdoctoral fellow. The postdoc will support ongoing activities in the group and help answering urgent questions on the role of fluid flow at the bone-cartilage interface in murine knees and how this is changing during onset and progression of posttraumatic OA.

Profile

The applicant should have an excellent PhD in Biomedical Engineering, Mechanical Engineering, or other relevant discipline. The applicant should have a thorough understanding of bone and cartilage mechanics and physiology; experience in finite element analyses, programming, imaging, and experimental testing are all highly advantageous. Good skills in spoken and written English are mandatory.

Offer

We offer a postdoctoral position at the Biomechanics Section at KU Leuven, initially for one year with the possibility of extending to two years. Salaries are highly competitive and in accordance with KU Leuven regulations. A project start in September 2025 is envisioned. Applications will be reviewed immediately until the position is filled.

Interested?

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